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KMID : 0043320010240010016
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Archives of Pharmacal Research
2001 Volume.24 No. 1 p.16 ~ p.20
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Synthesis of 2-(Allylthio)pyrazines As a Novel Cancer Chemopreventive Agent
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Lee JW
Lee BY
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Abstract
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2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome P-450 and induction of phase 11 enzymes involved in the detoxification of carcinogens. A practical reparation method of 2-(allylthio) pyrazine derivatives was established by the reaction of 2- mercaptopyrazine and allylbromides in the presence of a catalytic antioxidant, DABCO (1,4-diazabicyclo[2,2,21 octane), in dimethylformamide at below 50oC.
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KEYWORD
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